Sleeping up stiff hands and feet can be caused by the following reasons: 1, rheumatoid, rheumatoid is a common cause of swelling of the hands and feet, rheumatoid can lead to the morning after waking up or after waking up after sleep fingers, toes, multiple swelling, can be accompanied by morning stiffness, can be accompanied by pain in the joints, this time, we need to check the blood tests and shoot X-ray of the hands and feet to diagnose and treat; 2, ankylosing spondylitis, ankylosing spondylitis Ankylosing spondylitis can involve many joints in the whole body, especially the joints of hands and feet in the more serious stage, then there can be morning stiffness, there can be swelling of hands and feet in the morning, accompanied by pain in the sacroiliac joints and lumbar vertebrae, then it is necessary to go to rheumatology and immunology department to conduct blood tests and take X-rays of spine and sacroiliac joints in early stage for diagnosis and treatment.