Whether a diabetic patient can switch back to oral hypoglycemic drugs after using insulin depends mainly on the recovery of the patient’s pancreatic β-cell function after treatment. Specifically, the following points need to be met: 1, the patient’s insulin dosage does not exceed 20 units throughout the day, and the blood glucose control is up to standard; Tian Yong, Department of Endocrinology, Zhengzhou People’s Hospital; 2, the islet function is obviously restored, fasting C-peptide level > 0.4 nmol /L, and C-peptide > 0.8 nmol/L after standard sugar load; 3, the patient does not have serious chronic complications of diabetes and liver and kidney insufficiency; 4, stress The patient’s condition is stable and the glycemic control is good; 5. The patient is negative for diabetic autoantibodies, excluding type 1 diabetes and occult autoimmune diabetes in adults (LADA). Only after the above conditions are met, should we consider stopping insulin and switching to oral hypoglycemic therapy.