Cancer metastasis usually requires chemotherapy. Cancer metastasis is categorized into lymph node metastasis and blood line metastasis, as well as implantation metastasis of surrounding organs, peritoneal metastasis and so on. It is possible to treat cancer by means of chemotherapy after the occurrence of metastasis, especially for most of the advanced cancer cells with extensive metastasis, the growth of cancer can be controlled by chemotherapy in order to prolong the survival period. After cancer metastasis, appropriate treatment modalities, such as radiotherapy, chemotherapy as well as surgery, should be chosen according to the specific conditions of the disease. Since chemotherapy is a systemic treatment, it may cause adverse reactions such as bone marrow suppression, gastrointestinal reactions, and damage to target organs, so the chemotherapy regimen should be formulated according to the specific conditions of the disease.