Toothache and limited mouth opening need to identify the cause, commonly caused by wisdom teeth pericoronitis, apical periapical inflammation and temporomandibular arthritis, etc., and need to be under the guidance of the doctor to guide the treatment, such as medication. 1. Wisdom tooth pericoronitis: Wisdom tooth pericoronitis is a common clinical cause of toothache and limited mouth opening, because the position of the wisdom tooth is close to the end of the tooth bed, and closer to the chewing muscles. At this time, you need to use antibiotics for anti-inflammatory treatment under the guidance of the doctor, you can take oral cefixime capsules, amoxicillin capsules, metronidazole tablets and other anti-infective treatment. 2. Periapical inflammation of molar teeth: In addition to the inflammation in the apical bone tissue of molar teeth, with the spread of inflammation, it can spread to the face and chewing muscles, which can also lead to toothache and restriction of mouth opening. In the treatment, in addition to the use of antibiotic anti-inflammatory, but also on the tooth root canal treatment. 3. Temporomandibular arthritis (TMJ): In some patients, malocclusion due to malocclusion of teeth in the mouth may cause TMJ, and the common symptoms are severe pain and limited opening of the mouth. It is necessary to give anti-inflammatory and pain relieving drugs under the guidance of doctors, including non-steroidal anti-inflammatory drugs, such as ibuprofen extended-release capsules. However, it cannot be ruled out that it is caused by other factors, and this symptom alone is not enough to determine the disease. It is recommended that patients consult a doctor in time to identify the cause of the disease, and follow the doctor’s instructions to standardize the use of medication, do not blindly use on their own.