Medicines are poisonous. One of the “poison” role, can directly or indirectly affect the erectile function of the penis. Drugs are mainly the following types: 1, mental drugs drugs with sedative effect of drugs such as barbiturates, thiazides, can inhibit sexual desire, sexual arousal and affect erectile function. Antidepressants (such as tricyclic, monoamine oxidase inhibitors, lithium) can interfere with the transmission of autonomic impulses for erection and ejaculation. 2, antihypertensives The use of antihypertensives is the most common cause of erectile dysfunction, almost all antihypertensives can be concomitant with ED. sympathetic nerve blockers that act on the central nervous system can inhibit the central nervous system, increase prolactin levels, and reduce libido; sympathetic inhibitors are often accompanied by ED and ejaculation disorders, methyldopa, colestipol, rifampicin, etc. Act on the central nervous system to inhibit the sexual impulse, so that the erectile mechanism is dysfunctional; sympathetic inhibitors often accompanied by ED and ejaculation disorders, methyldopa, coleseine, lipitor and other effects of the central nervous system. The erectile mechanism is dysfunctional; the role of peripheral sympathetic nerves of guanethidine can cause ejaculatory disorders and ED at the same time. β-blockers are also commonly used in the treatment of hypertension, some studies have confirmed that β-blockers can cause a decrease in the level of blood testosterone, in particular, the strongest effect of the cardiac glycosides; in addition, thiazide diuretics can significantly affect the erectile function. Theoretically, diuretics and vasodilators do not cause erectile dysfunction, but patients with severe atherosclerosis, need to have a higher blood pressure in order to have adequate blood flow to the penis, vasodilators make blood vessels dilated, diuretics reduce blood volume, both lower blood pressure and can be combined with hypokalemia, thus leading to erectile dysfunction. 3, anti-androgen activity drugs such as cimetidine, cycloheximide acetate, spironolactone and so on can lead to low sexual function and affect the erection, digoxin can reduce the level of blood testosterone and make the level of estrogen rise. β-blocker also has the effect of anti-stimulant. In addition, BPH (prostate hyperplasia) patients taking estrogen for a long time can also antagonize the effect of androgens. 4, cause hyperprolactinemia drugs such as phenothiazines, opiates, endorphins, reserpine, cimetidine can affect erection through the central role. 5, other drugs Anticholinergic receptor drugs such as atropine and probenecid, antihistamine drugs such as benadryl and paracetamol can affect erection. Alcohol, marijuana, opioids, heroin can cause sexual arousal in small doses, but if the dose is large or long-term application, it will inhibit libido and cause erectile dysfunction. Chronic alcoholism causes alcoholic polyneuropathy (including penile nerves) and can lead to hepatic impairment, reduced inactivation of estrogen, and reduced testosterone levels.