The symptoms of unresponsiveness are a common group of clinical symptoms, mainly manifested by the patient’s inability to make correct and timely responses to himself. Patients with unresponsiveness should consult a doctor in a timely manner to clarify the cause of the disease before targeted treatment can be carried out. There are many causes of unresponsiveness, such as prolonged late nights and overtime work, resulting in sleep deprivation and lack of adequate rest for the brain, which can easily lead to brain unresponsiveness. It can also be seen in organic diseases, such as the presence of Alzheimer’s disease or vascular dementia, and it is recommended to improve the cognitive scale assessment and head imaging, and give timely medication.