Major’s syndrome can be diagnosed by a combination of clinical presentation, routine examination, and stimulus diagnosis. Meijer syndrome is an extravertebral system neurologic disease and a nonorganic disease. 1. Clinical manifestations: Meijer’s syndrome can be manifested as double eyelid spasm, dystonia of the lower jaw muscles, mouth opening, teeth clenching, lip pouting and other symptoms, and in severe cases, there can be dislocation of the lower jaw, tooth wear, slanting neck, head tilting backward and forward bending and other symptoms. 2. Routine examination: patients with Meijer syndrome can be diagnosed through a series of routine examinations, such as electroencephalogram, electromyography, cranial CT, papillomastoid X-ray radiographs and other examinations to exclude papillomastoid and cranial disorders. 3. Stimulation diagnosis: Meijer syndrome can be diagnosed by stimulation diagnosis such as electrical stimulation and transient eye reflex. Electrical stimulation examination can determine whether the contraction of the orbicularis oculi muscle on the affected side and other muscles innervated by the facial nerve occur synchronously. The transient reflex examination can find out whether there is an increase in the frequency of transient eyes, prolonged latency time of the R1 component and so on. It is recommended that the patient consult the doctor in time, use scientific and reasonable methods for comprehensive diagnosis under the guidance of the doctor, and follow the doctor’s instructions for correct treatment.