Vaginal opening bulging a large bag to consider and vestibular gland cyst or abscess, vaginal wall or uterine prolapse, uterine submucosal fibroid prolapse, etc., the treatment should be based on the cause of the disease through medication, surgery and other ways to actively treat. 1. Vestibular gland cyst or abscess: as the opening of vestibular gland is located in the inner side of labia minora, if the duct opening is blocked, it will cause the glandular fluid to be unable to be discharged and stagnate in the local area to form a retention cyst, and if combined with bacterial infection at the same time, it will lead to an abscess, which needs to be treated with cephalosporin, ofloxacin and other antibiotics as prescribed by the doctor to fight infections, and needs to be incised and drained if necessary. 2. Prolapse of the anterior and posterior walls of the vagina or uterus: for older women or women who have given birth many times, the pelvic floor tissues and ligaments are damaged, which may easily cause the anterior and posterior walls of the vagina and the uterus to prolapse outside the vaginal opening, and then the anterior and posterior walls need to be repaired or the uterus needs to be removed through surgery as prescribed by the doctor. 3. Uterine submucous fibroid prolapse: if women have submucous fibroid with clitoris, the fibroid may prolapse through the cervical canal into the vagina or outside the vagina, so it can be manifested as a space-occupying lesion in the vaginal opening, and at this time, it is necessary to comply with the doctor’s prescription to remove the submucous fibroid through hysteroscopic surgery. For women who have a large bulge in the vaginal opening, it is recommended that they go to the gynecology department of a regular hospital for consultation and active treatment under the guidance of a doctor after the cause of the disease has been clarified.