Foot fungus is medically known as tinea pedis, a chronic infectious skin disease caused by fungal infection of the feet. At present, the clinical used for antifungal treatment drug type is more, the treatment of tinea pedis does not exist the most effective medicine, according to the condition and the characteristics of the patient, choose the appropriate drug, and give enough course of treatment, dose, adhere to the medicine, can be cured. Tinea pedis treatment drugs have prescription drugs and non-prescription drugs, non-prescription drugs for external use, less toxic side effects, relatively light, will not cause drug resistance, and other drugs interact with a small, mainly used for fungal infections lighter and stable tinea pedis, non-prescription drugs in the pharmacy to buy. Prescription antifungal drugs are toxic and must be purchased with a doctor’s prescription, and the method and time of administration need to be used under the guidance of a doctor and pharmacist. Treatment of tinea pedis with over-the-counter drugs are azoles, acrylamines, acting on the cell membrane of fungal cells, oral absorption is not good, toxicity is greater, made into ointments, sprays, suppositories and other topical preparations. The representative drugs of azoles are miconazole, clotrimazole, ketoconazole; acrylamines mainly include terbinafine, butenafine and naftifine, etc. The cure rate of the two types of drugs can reach more than 70%, which is suitable for patients with tinea pedis with limited first-onset or lesions. Previous studies have shown that acrylamines, mainly terbinafine, are more effective than azoles. Azoles require a longer treatment course, and arylamines have a dual antimicrobial effect and are theoretically more antifungal. Topical dosage forms are appropriate for treating the interdigital type of tinea pedis, which is prone to secondary bacterial infections. Oral dosage forms of terbinafine are commonly prescribed for the treatment of tinea pedis, and topical treatments are less effective and recurrent. Scaly keratosis type with a large area of involvement, or with certain systemic diseases, such as diabetes, AIDS, etc., unwilling to accept local treatment of patients, oral terbinafine is well absorbed, mild adverse reactions, need to go to the hospital, with a doctor’s prescription to buy and use.