Only 10% of lymphomas are located in the posterior cranial fossa and most of the rest are located in the deep supratentorial periventricular area.CT is generally isointense and hypointense with homogeneous enhancement. Because of infiltrative growth, some surrounding brain tissue is edematous and compressed. Sometimes it shows necrosis in the center of the circumscribed lesion, which is then difficult to distinguish from glioma. If the lesions are multiple, they need to be differentiated from metastases and infections, relying mainly on peripheral edema. Magnetic resonance spectroscopy is hypodense and isointense in T1 and dense in T2 in 40% of cases. Magnetic resonance spectroscopy (MRS) can show the same clumpy elevated lipid response as glioma. However, it is highest in the choline/sarcosine ratio and can be used to differentiate from glioma. Cerebral blood flow is low compared to high-grade glioma, and DTI can be seen as scattered fragments in the white matter contrast on both sides, while measuring ADC rates. Both indicators are significantly lower in lymphoma than in glioma, but ADC does not differentiate bowen’s disease from lymphoma. Lymphomas were significantly higher on SPECT images 123I-IMP 6-24 hour retention than meningiomas and malignant gliomas. In AIDS patients, thallium SPECT lag can differentiate lymphoma from infection and is very sensitive.