Immunoglobulin (immunoglobulin) refers to animal proteins with antibody activity. It is mainly found in blood plasma, but also in other body fluids, tissues and some secretory fluids. The normal range of serum immunoglobulin (Ig) includes: IgG, IgA, IgM, IgD, IgE. its normal range: IgG 7, 6 ~ 16, 6g/L; IgA 0, 71 ~ 3, 35g/L; IgM 0, 48 ~ 2, 12g/L; IgD 0, 01 ~ 0, 04g/L; IgE 0, 001 ~ 0, 009g/L. Then, chronic heavy hepatitis causing serum immunoglobulins can be elevated should be diagnosed? The following is a brief introduction: In chronic active hepatitis and cirrhosis based on a variety of factors can occur due to a large area of liver tissue necrosis, clinically known as “chronic heavy hepatitis”. The main clinical manifestations are: 1, the patient has a previous history of chronic active hepatitis, or even if there is no history of chronic hepatitis signs and symptoms and ALT elevation, but there is hepatitis virus serology: the basis for diagnosis. 2, High degree of malaise and severe gastrointestinal symptoms. 3.Rapid rise in serum bilirubin greater than 171 micromolar/100 ml. 4.Signs of chronic liver disease such as dull complexion, liver palms, spider hemorrhoids and hepatosplenomegaly. 5.Early appearance of ascites and the amount is often high. 6, Albumin/globulin (A/G) inversion or Y-globulin is elevated. 7, Enzyme-biliary separation phenomenon is obvious. 8, late onset of hepatic coma, mostly die from gastrointestinal bleeding and renal failure, etc. 9.Progression is relatively slow, and prothrombin activity (PTA) is progressively decreasing.