Blisters (medically known as blisters) can heal in about 7 to 10 days after skin cryotherapy, but the exact time is not generalizable, and is related to the patient’s physical condition, whether or not the skin is properly cared for, and other factors. Skin cryotherapy is a way of treating skin diseases by using liquid nitrogen to freeze the skin, mainly through the effect of low temperature on the diseased tissue, causing it to degenerate and necrosis, so as to achieve the effect of treating the disease. Liquid nitrogen is chemically stable, not easy to burn and explode, no toxicity, irritation and corrosive, safety is better. After liquid nitrogen cryotherapy, the skin is prone to blisters or blood blisters, if the blisters and blood blisters are not infected, most of them will subside in about 7 to 10 days. It is recommended that patients pay attention to local hygiene and cleanliness after treatment to avoid secondary infection, and seek medical treatment promptly if there is any discomfort.