A minimally invasive breast pathology biopsy is usually done to diagnose the nature of the breast nodule, and a second minimally invasive breast pathology biopsy can further improve the diagnostic rate. Surgical pathology diagnosis of breast nodules is more critical to clarify whether the patient’s nodules are benign or malignant. Breast nodules are a common symptom caused by breast diseases, including benign and malignant breast nodules. The cause of breast nodules is still unclear, and they are commonly caused by breast hyperplasia and breast tumor diseases, including benign breast tumors, such as breast fibroadenoma, lobular tumors, etc., as well as malignant breast tumors, such as breast cancer. In the case of malignant breast nodules, surgical excision is the mainstay of treatment. If excision is not possible, especially in patients with advanced breast cancer, etc., local radiation therapy or systemic chemotherapy is needed to reduce the manifestation of the tumor and prolong the patient’s life as much as possible. In the case of benign breast nodules, attention should be paid to check whether the benign nodules have malignant tendency, and if necessary, the benign nodules can be punctured, minimally invasive or surgical excision for pathologic biopsy. Once a nodule is found to have a malignant tendency, surgical excision is also required. If the tumor is clearly benign, the nodule should also be surgically removed to avoid the possibility of deterioration of the benign nodule. Patients should follow the doctor’s instructions and actively cooperate with the doctor’s treatment, do not blindly diagnose or treat on their own, in order to avoid delaying the condition or causing adverse reactions.