How to use erythromycin eye ointment depends on the need of the condition. Erythromycin eye ointment can be applied on the eyelids and also in the conjunctival sac. Because the eye ointment contains high quality petroleum jelly, it can also be used on dry chapped skin and for acne treatment as well. Erythromycin eye ointment is an antimicrobial drug, an antimicrobial drug of macrolide produced by Streptomyces erythromycin, made into a paste mainly to prolong the retention time of the drug in the eye or on the skin, and is used to treat eye diseases such as trachoma, conjunctivitis, keratitis, especially neonatal conjunctivitis caused by Chlamydia trachomatis, and syphilitic ocular surface disease.