Botox has been permitted by the FDA since 1979 for the treatment of strabismus and blepharospasm over the age of 12. As research progresses, Botulinum toxin type A is widely used in many fields such as ophthalmology, neurology, orthopedics, and plastic and cosmetic surgery. The preliminary summary has the following main indications: 1, facial wrinkles. 2. Eyebrow drooping, elevation or asymmetry. 3.Eyelid spasm. 4.Spastic sloping neck. 5. Broad cervical banding. 6, Lower eyelid hypertrophy. 7, Simple bite hypertrophy. 8.Auriculotemporal nerve syndrome. 9.Facial deformity caused by abnormal regeneration of facial nerve. 10.Auxiliary treatment, i.e. for laser wrinkle removal and soft tissue filler.