After opioid poisoning, the first step should be to determine the route of poisoning, judge the severity of poisoning, and then carry out treatment, as follows: 1. For those with mild oral poisoning, you can first let them drink a lot of water to induce vomiting, and then instill 1:2000 potassium permanganate solution to wash the stomach, and also take diuretics and laxatives to promote the excretion of poison and reduce the absorption of toxins by the body; 2. For severe poisoning, those with Respiratory depression can use respiratory stimulants and other drugs to stimulate the respiratory center and keep breathing unobstructed; for patients with severe respiratory distress and even coma, they should adopt a flat position to remove foreign bodies from the mouth and let the head tilt to one side; for severe respiratory depression, they may even use tracheal intubation and use ventilator-assisted treatment; for treatment with opioid antidotes, they can choose naloxone or naloxone, etc. If necessary, the drug can be repeated every 10-15 minutes; rehydration and diuresis should be carried out to promote the excretion of toxins; for patients with particularly severe poisoning, blood purification treatment should also be carried out; 3. For special groups of people encountered in the clinic, such as those who have intentionally become addicted to opioids, confidence should be built up and treatment should be taken seriously; for patients with deep addiction, coercive measures should also be taken, preferably Take drug treatment and other compulsory measures.