Tardive dyskinesia does not have the most obvious signs in the early stages of the disease, but common symptoms include awkward and weak movement of one or both fingers, muscle atrophy, and even the development of muscle fasciculations. Tardive dyskinesia is a condition characterized by motor neuron disease. Motor neuron disease, also known as “tachyphylaxis”, is a series of chronic progressive neurodegenerative diseases that are characterized by damage to upper and lower motor neurons, with amyotrophic lateral sclerosis being the most common type, also known as classic type. The common first symptom is one side or both sides of the finger activity clumsiness, weakness, followed by the emergence of small muscle atrophy of the hand, to the large and small fish interosseous muscle, interosseous muscle, earthworm muscle is obvious, both hands can be in the shape of an eagle’s claw, and gradually extend to the forearm, the upper arm and scapular girdle muscle group. With the prolongation of the disease, muscle weakness and atrophy extend to the trunk and neck, and finally involve the facial muscles and pharyngeal muscles. There is often marked muscle fasciculation in the affected areas. There was atrophy of both upper limbs with low muscle tone but hyperreflexia and positive Hoffmann’s sign; spastic paralysis of both lower limbs with mild muscle atrophy and fascicular fibrillation, high muscle tone, hyperreflexia and positive Babinski’s sign. Patients usually do not have objective sensory deficits, but often have subjective sensory symptoms such as numbness. If the body shows weakness of activity, muscle atrophy and other manifestations, it should be taken seriously and promptly go to the hospital for treatment.