Estrogen is a hormone produced primarily by a woman’s ovaries. Drugs that increase estrogen usually include hormonal drugs such as estradiol valerate, dydrogesterone, and conjugated estrogens. The effects of estrogen deficiency on women are more significant. Women with estrogen deficiency may experience a range of clinical manifestations, such as irregular menstruation, hot flashes, and sometimes can even cause mood changes. Estrogen supplementation should be accompanied by progesterone supplementation. Estrogen has the ability to improve clinical manifestations such as hot flashes and irregular menstruation in women. Binding estrogen and estradiol valerate are commonly used in clinical estrogen supplementation. Progesterone assists estrogen in its role, and commonly used drugs include dextroprogesterone. Patients with low estrogen should take medication under the guidance of a physician and should not use medication blindly to avoid adverse consequences.