Rabeprazole and atorvastatin can be used in combination at the same time, and there is no contraindication for the two. Rabeprazole is a proton pump inhibitor, which can reduce the secretion of gastric acid, and can be used in the treatment of peptic ulcer and reflux esophagus disease. Atorvastatin mainly inhibits cholesterol synthesis, can stabilize plaque, can be used for hypercholesterolemia and ischemic cardiovascular disease treatment, the two drugs have no contraindications, can be used together. Patients with cardiovascular and cerebrovascular diseases need to take oral statins and antiplatelet drugs, etc., long-term use may be more stimulation of the gastric mucosa, there is a risk of gastric ulcer bleeding, high-risk patients can take rabeprazole at the same time, to prevent the occurrence of gastrointestinal mucosal damage. Adverse reactions of rabeprazole include fever, cough, dyspnea, hematocrit, liver function abnormalities, etc. It is contraindicated for patients who are allergic to the drug components or taking atazanavir. Adverse reactions of atorvastatin include nausea, vomiting, stomach upset, constipation, elevated transaminases, etc. It is contraindicated in patients who are allergic to the drug components, have unexplained elevated liver enzymes, or have severe hepatic impairment. Clinical use of rabeprazole and atorvastatin should be under the guidance of a physician, and at the same time, pay attention to regular review of liver function.