Swollen eyes when you get up from sleep may be related to nephritis, fatigue, improper sleeping position and other factors. Generally, you can take medication, apply cold compresses to the eyes, and rub the eyes to reduce the swelling. 1. Nephritis: the glomerular filtration rate of patients with nephritis is reduced, which will lead to drainage dysfunction and water retention in the body, thus resulting in swollen eyes when sleeping. You can take hydrochlorothiazide tablets, spironolactone capsules and other diuretics under the guidance of a doctor to expel water from the body to reduce swelling. 2. Eye inflammation: Inflammation in the eye (such as blepharitis) under the stimulation of eye swelling, congestion and other uncomfortable symptoms. Patients can use tobramycin eye drops, erythromycin ophthalmic ointment and other medications as prescribed by the doctor to control inflammation and promote the recovery of the patient’s condition. 3. Improper sleeping posture: If you like to sleep on your stomach, it may cause poor blood circulation in the eyes and water retention in the microvessels, resulting in swelling of the eyes when you sleep. You can gently rub the eyes to reduce swelling. It is recommended that patients develop good eye habits, if necessary, timely medical standardized treatment, the use of specific drugs need to follow the doctor’s instructions.