The advantage of glimepiride is that it is taken less frequently, which can improve patient compliance. On the other hand, it can be very effective in helping hyperglycemic people control their blood sugar. The disadvantage is that it is an insulin agonist, which may lead to hypoglycemia, and therefore requires active monitoring of blood glucose. Glimepiride is a sulfonylurea hypoglycemic drug commonly used in clinical practice. The main hypoglycemic mechanism is to stimulate the pancreatic β-cells to secrete insulin, increase the body’s insulin level and reduce blood glucose. Its disadvantage is that it promotes insulin secretion, so there is a possibility of hypoglycemia, and hypoglycemia is more dangerous for diabetic patients, especially the elderly. Therefore, in clinical use, it is necessary to consult the endocrinology department to have a professional doctor to determine whether to use glimepiride, and use the appropriate dosage under the doctor’s guidance.