When atrial fibrillation attacks, patients will unconsciously have chest tightness, palpitations and other manifestations, and sometimes also produce nervousness and anxiety. Clinically encountered some paroxysmal atrial fibrillation patients, the mood has been more tense, sometimes the heart rhythm is normal, but also have palpitations, chest tightness. So what exactly is the relationship between atrial fibrillation and anxiety? Possible mechanisms of depression and anxiety associated with atrial fibrillation: 1. Symptoms such as chest tightness and palpitations during atrial fibrillation can cause anxiety. 2, the lack of understanding of atrial fibrillation, patients may equate atrial fibrillation with sudden cardiac death, thus causing panic. 3.Worry about the complications of atrial fibrillation (embolism, heart failure, etc.). 4. Atrial fibrillation can lead to autonomic remodeling, and autonomic nerves have a regulatory effect on emotions. 5, Animal model of atrial fibrillation in dogs with increased acetylcholinesterase activity, vagal denervation in atrial muscle. 6, Sympathetic nerve activity is increased in patients with atrial fibrillation and animal models, and sympathetic nerves are increased in atrial muscle. The effect of anxiety on atrial fibrillation: 1, anxiety and depression can adversely affect atrial fibrillation by affecting autonomic nerve activity, inflammation and endothelial function response of the body. 2, Friedman et al. in the United States pointed out that there is an autonomic nervous system dysfunction during anxiety, which is manifested as a decrease in vagal tone and heart rate variability (HRV). 3. Anxiety makes the sympathetic nervous system hyperfunctional and increases the concentration of adrenaline in the blood. 4. The more severe the anxiety, the more pronounced the activation of the sympathetic nerves. 5, the sympathetic nerve can shorten the atrial refractory period, can cause the alternation of action potential timing, adrenergic nerve agitation can induce atrial ectopic agitation, can trigger the foldback and induce atrial fibrillation. When anxiety accompanied by atrial fibrillation quietly, in the positive solution to atrial fibrillation this originator at the same time, patients and friends can also try to relax emotions, conversion of attention, do not let anxiety to help atrial fibrillation for abuse, improve the quality of life.