There is no direct relationship between knee joint soreness and cervical spine. The causes of knee joint soreness may include osteoarthritis, knee synovitis, rheumatoid arthritis and so on. 1. Osteoarthritis: it is a chronic joint disease characterized by degenerative changes of articular cartilage and secondary osteophytes. In addition to soreness and swelling of the knee joint, there can be pain in and around the joint, stiffness, bony hypertrophy of the joint and dysfunction and other symptoms. 2. Knee synovitis: Inflammatory changes in the synovium caused by mechanical or chemical stimulation of the knee joint leading to degeneration of the synovium or destruction of the synovium due to acute or chronic injury. Joint pain, soreness and dysfunction are the main clinical manifestations. 3. Rheumatoid arthritis: it is a kind of allergic disease, closely related to group A streptococcus, with the typical manifestation of roving polyarthritis, often symmetrically involving the knee and other joints. In addition to the symptoms of localized soreness, redness, swelling and pain in the knee joints, there can also be generalized fever, etc. If the symptoms of soreness and swelling in the knee joints are obvious, there can be generalized fever. If the symptoms of knee joint soreness and swelling are obvious, or accompanied by other symptoms, or suspected cervical spondylosis, it is recommended to go to the hospital in time, to clarify the cause and give targeted treatment.