Sudden panic and fear upon awakening from sleep requires the exclusion of organic diseases such as myocardial ischemia, arrhythmia, and cardiac insufficiency. During nighttime sleep, it is often easy to have acute myocardial ischemic events due to coronary artery spasm, and sudden chest tightness, chest pain, and gasping for air during the nighttime sleep state, requiring sitting up to breathe. In addition, at night, due to resting in a flat position, the increase in venous return blood volume, and the increase in cardiac insufficiency, the occurrence of respiratory distress, such as nocturnal paroxysmal dyspnea, and even the occurrence of symptoms such as telescopic breathing. Therefore, if you wake up with sudden panic and fear, you need to exclude organic diseases. It is recommended to perform coronary artery imaging, cardiac ultrasound and B-type brain natriuretic peptide precursor examination to clarify the status of heart failure. Based on the exclusion of organic diseases, functional diseases are often considered to be the cause, and it is recommended to give a comprehensive treatment with psychotherapy as the main treatment and medication as the supplement.