Patients with chronic kidney disease stage 1 may have no obvious clinical manifestations, and some of them may have weakness, loss of appetite, lumbago, increased nocturia and so on. Chronic kidney disease is defined as renal injury (renal structural or functional abnormality) for ≥3 months, with or without decreased glomerular filtration rate, clinically manifested by abnormal pathology or renal injury (including abnormalities in blood and urine composition or abnormalities in imaging); glomerular filtration rate <60 ml/(min-1.73m²) for ≥3 months, with or without evidence of renal injury. Chronic kidney disease staging was specifically based on the level of glomerular filtration rate, where chronic kidney disease stage 1 was characterized by normal renal function and a glomerular filtration rate of ≥90 ml/(min-1.73m²). Patients with stage 1 chronic kidney disease usually have no obvious clinical manifestations, some patients may have weakness, loss of appetite, lumbago, increased nocturia, etc.; if the patient's symptoms are serious, nausea, vomiting, mild anemia and edema may occur. Patients with chronic kidney disease stage 1 can take medication, such as captopril tablets, enalapril maleate tablets and other angiotensin-converting enzyme inhibitors to protect the kidneys under the guidance of the doctor. In addition, patients can also take oral valsartan capsules, timosartan tablets and other angiotensin II receptor antagonists as prescribed by the doctor. It is recommended that patients with chronic kidney disease go to the hospital in time and follow the doctor's instructions for standardized treatment.