Leukemic reticuloendothelial cell hyperplasia is a polyhairy cell leukemia, a special type of leukemia, the typical pathological manifestations of leukemia cells on the surface of a large number of villus-like small protuberances, to the middle-aged and elderly people, most of them have a chronic course of the disease, and can significantly prolong the survival of the active treatment. 1. Hairy cell leukemia is a rare special type of leukemia, the cause of the disease is not clear, and the course of the disease is chronic. 2. Clinical manifestations are unexplained splenomegaly, with a giant spleen, susceptible to infections, and the hallmark polycythemia vera cells can be found in pathologic examinations. 3. Current treatment options include splenectomy, as well as drug therapy, specifically including cytarabine, zithromax, and cladribine. Hairy cell leukemia belongs to a special type of leukemia, and the overall prognosis is better compared to other acute leukemias. Diagnosed patients need to be actively treated, seek medical attention as early as possible, and standardize the treatment under the guidance of the doctor to prolong the survival period as much as possible.