Early symptoms of acromegaly include progressive spinal muscular atrophy, progressive medullary palsy, primary lateral sclerosis and amyotrophic lateral sclerosis. Progressive spinal muscular atrophy is the first sign of acromegaly, with atrophy and weakness of the interosseous muscles of both hands. Early symptoms of progressive medullary palsy include nasal accent, hoarseness, atrophy of the tongue muscles, muscle fasciculations, and salivation. Early symptoms of primary lateral sclerosis are mainly weakness in both lower limbs. Early symptoms of amyotrophic lateral sclerosis are clumsiness and inflexibility in finger movements, inaccuracy in performing fine movements and weakness. If the patient has early symptoms of acromegaly, it is recommended to go to the hospital in time, clear diagnosis, and standardized treatment under the guidance of the doctor.