Chemotherapy cannot cure endometrial cancer in advanced stage, but it can prolong the survival period and improve the quality of life of patients. Endometrial cancer is a relatively common malignant tumor, which occurs in the elderly. For those who cannot undergo surgical resection or cannot tolerate surgery, chemotherapy can be considered to control the progression of the disease and prolong the survival period of patients. As it is difficult to kill all the tumor cells completely, advanced cancer cannot be cured clinically. For this kind of patients, chemotherapy, radiotherapy and endocrine therapy can be used to control the progression of the disease and prolong the survival period. Therefore, chemotherapy cannot cure advanced endometrial cancer, but it can improve the quality of life and prolong the survival period.