The appropriate age for vaccination for the nine-valent is 9-45 years old. Nine-valent refers to the nine-valent human papillomavirus (HPV) vaccine, which is mainly used for the prevention of HPV infections. The nine subtypes of the virus that can be prevented are HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58, and the appropriate age for this vaccine is 9-45 years old. The risk of exposure to HPV increases with age, especially with the onset of sexual activity, so it is recommended that age-eligible women receive the vaccine as early as possible. Vaccination is contraindicated in persons with thrombocytopenia or other coagulation disorders that could be a contraindication for intramuscular injection. Acute illnesses are often accompanied by systemic symptoms such as fever, which may be exacerbated by vaccination, and vaccination is recommended after recovery. HPV vaccination is prohibited for those who have hypersensitivity to the active ingredients of the vaccine or to any of the excipient components, and those who have symptoms of hypersensitivity after injection of the product should not be revaccinated with the product. Regular cervical cancer screening is still required after HPV vaccination.