Rhabdomyosarcoma of the colon is a malignant tumor that occurs in the colon. The tumor originates from immature mesenchymal stem cells and is prevalent in children and rare in adults. Rhabdomyosarcoma of the colon is rare, but it is highly aggressive and has a low survival rate. 1. Clinical manifestations: mainly with compression symptoms. Patients can touch the mass in the abdomen, and may have abdominal distension, abdominal pain and other manifestations. For those with large tumor size, even abdominal pain, nausea and vomiting, abdominal distension and other intestinal obstruction manifestations may occur. 2. Examination: it can be diagnosed by abdominal CT, under which it can be shown as a low-density lesion with uneven density and irregular edge, and the demarcation between the tumor and the colon wall is not clear. Pathological examination can determine the nature of the lesion, and colonic rhabdomyosarcoma can be classified into follicular, embryonic and pleomorphic types pathologically. 3. Treatment: Early tumors can be treated by surgical resection, while for advanced patients, radiotherapy is usually performed. Overall, the survival rate of patients with colonic rhabdomyosarcoma is low. For patients diagnosed with colon rhabdomyosarcoma, they should go to the relevant departments of regular hospitals as soon as possible, so as to achieve “early detection, early diagnosis, early treatment”, thus prolonging the survival period of patients and improving the quality of life of patients.