Abnormal fat metabolism refers to abnormalities in the body’s lipids, from synthesis to catabolism, resulting in too much or too little lipid fat in various tissues, thus affecting the body’s function. The most common is to feel a little fat, or often said to become thin for no reason. The general manifestations are skin swelling, skin laxity, and thinness caused by lipid deposits in the dermis. Treatment includes non-pharmacological and pharmacological treatment, non-pharmacological treatment is diet and exercise, low-fat, low-salt, light diet, eat more vitamins and fiber-containing vegetables and fruits, eat less fat meat and fried food, develop a reasonable exercise program, adhere to daily exercise, do moderate aerobic exercise. Medication is the use of lipid modifiers, including statins and other related drugs, according to the blood fat, high cholesterol or low-density lipoprotein, to choose the appropriate medication. If the fat metabolism is accelerated and the body appears to be thin, the common diseases include hyperthyroidism, diabetes mellitus and other diseases, the treatment of the original disease can improve the abnormal fat metabolism. Therefore, it is necessary to regularly review the blood lipids, check the fat metabolism, according to the degree of abnormal fat metabolism to formulate the appropriate treatment plan.