Formaldehyde poisoning can produce the clinical effect of headache. Formaldehyde is a toxic chemical that produces toxic reactions when taken or inhaled in excess, during which the reactions of the nervous system, the respiratory system and the mucous membranes are particularly significant in clinical practice. This can lead to edema of the optic papillae, which can cause clinical manifestations of ejection and vomiting. Severe poisoning may cause formaldehyde pulmonary edema, or neurological edema leading to death, usually accompanied by headache after smelling formaldehyde, tearing, burning eyes, pain and coughing, and occasionally abdominal pain with vomiting.