Granular spots may be freckles, which can be removed by medication and physical methods. Freckles usually have no effect on the patient’s health and usually do not require special treatment. Those with more serious freckles or those that have a greater impact on the patient’s own aesthetics may choose to use cosmetics to cover them up, and may seek medical attention if necessary. Trichloroacetic acid solution or phenol spot-coating can make freckles peel off, but some of them may lead to scarring or pigmentation disorder, and should be used under the guidance of medical professionals to avoid adverse reactions. Q-switched laser, intense pulsed light or pulsed gemstone dye laser can effectively remove freckles, but it can not prevent recurrence, and it is necessary to pay attention to avoiding light after the operation. Liquid nitrogen freezing is also effective for freckles. For severe cases, it is recommended to seek medical advice and follow the doctor’s instructions for medication and treatment.