Whether proteinuria with a plus sign requires medication depends on whether the proteinuria is transient or persistent. If the proteinuria is transient, such as caused by fever or strenuous exercise, the urinary routine should be reviewed after rest or body temperature is normal. If it is persistent pathological proteinuria, this time is certainly the need for drug treatment. First, if the proteinuria is caused by diabetes or hypertensive nephropathy, it is definitely necessary to take antihypertensive drugs or hypoglycemic drugs at this time. Secondly, after the appearance of proteinuria, you can take the antihypertensive drugs such as Prilosec or Satan to achieve the effect of lowering urinary protein. Third, if the primary kidney disease causes proteinuria a plus, twenty-four hours urine protein quantification is greater than 1g, it is recommended to perform a kidney puncture to clarify the type of pathology, eat hormones or combined immunosuppressants for treatment.