Callus on the middle finger can be eliminated through medication, physical therapy, surgical treatment and other methods. 1. Medication: Vitamin A cream, urea ointment and other medications can effectively remove the cuticle of the skin surface to eliminate the effect of callus on the middle finger; if the symptoms of pain, can be used externally with salicylic acid ointment and other salicylic acid drugs can relieve the pain symptoms. 2. Physiotherapy: Physiotherapy methods such as liquid nitrogen freezing can be used to remove the overgrown cuticle and flatten the skin. 3. Surgical treatment: If the pain in the affected area has affected your life and work, or if medication can no longer control the pain, callosotomy can be used. It is recommended that those who have callus on the middle finger and have the need for elimination go to the regular hospital in time, and standardize the treatment with medication under the guidance of the doctor.