1.Patients with prostatic hypertrophy, alpha blockers can be given priority. 2, patients with coronary artery disease: β-blockers and ACEI are preferred, and long-acting calcium antagonists can be used in combination. β-blockers and ACEI are used in acute coronary syndrome; ACEI, β-blockers and aldosterone antagonists are used in post-infarction patients. 3, heart failure: cardiac function grade I-II can use ACEI and β-blockers, cardiac function grade III-IV can combine ACEI/ARB and aldosterone receptor antagonists with tab diuretics. 4, diabetes mellitus: in order to avoid renal and cardiovascular damage, it is required to reduce blood pressure to below 140/90 mmHg, and when urine protein >1g/L, it is appropriate to reduce blood pressure to below 130/80 mmHg, often requiring a combination of drugs, ACEI is preferred, or ARB, and if necessary, calcium antagonists, thiazide diuretics, beta-blockers. ACEI is beneficial for type 1 diabetes mellitus to prevent renal damage . 5, chronic kidney disease: ACEI, ARB to prevent the progression of kidney disease, severe patients need a combination of drugs tab diuretics. In addition, bilateral renal artery stenosis, pregnancy is prohibited ACEI, asthma, severe bradycardia, atrioventricular block, pathological sinus node syndrome is prohibited β-blockers; high blood potassium (>5.5mmol/L) caution ACEI, aldosterone receptor antagonists; gout caution diuretics; ACEI users appear angioneurotic edema should be immediately discontinued.