Cephalosporin is a large class of antibacterial drugs, amoxicillin is a penicillin class of antibiotics, the two in the contraindications, adverse reactions and other aspects of the difference. Cephalosporin and amoxicillin both belong to the β-lactam antibiotics, can inhibit the synthesis of the bacterial cell wall and thus play a bactericidal role, both have a similar antibacterial spectrum, on the Gram-positive bacteria and Gram-negative bacteria have a strong bactericidal effect. However, cephalosporins, as a large class of drugs, are categorized into one to five generations based on differences in antibacterial spectrum and resistance. Amoxicillin cannot be used in people who are allergic to penicillins, and gastrointestinal disorders, hives, rashes and allergic reactions may occasionally occur after use. Cephalosporin can not be combined with nephrotoxic drugs such as aminoglycosides, potent diuretics, etc., otherwise it may aggravate kidney damage. Ethanol and ethanol can occur “disulfiram”-like reaction, during treatment or within 3 days of stopping the drug should avoid alcohol. In addition, cephalosporins have fewer adverse reactions, common allergic reactions, such as rash, urticaria and so on. The nephrotoxicity of one to four generations of cephalosporins is gradually reduced. To summarize, both cephalosporins and amoxicillin should be used under the guidance of a doctor, do not abuse antibiotics.