High luteinizing hormone and low progesterone indicate the presence of ovulation disorder, which may be polycystic ovary syndrome, early onset ovarian reserve insufficiency and other diseases. If there is no need for pregnancy preparation, the menstrual cycle needs to be adjusted, if there is a need for pregnancy preparation, ovulation stimulation treatment is needed. Luteinizing hormone has the effect of promoting the production of corpus luteum, which can only be formed by follicles after ovulation, and progesterone is also formed by corpus luteum. When luteinizing hormone is high and progesterone is low, it indicates that there is an obstacle to ovulation, which may be polycystic ovary syndrome, early onset ovarian insufficiency, or other diseases. At this time, if there is no need to prepare for pregnancy, it is necessary to adjust the menstrual cycle to promote regular menstruation, thus promoting normal ovulation and preventing infertility. For women with the need to prepare for pregnancy, the treatment of adjusting the menstrual cycle lasts for a longer period of time, and ovulation stimulation therapy is recommended, with the use of drugs such as clomiphene. When the symptoms of high luteinizing hormone and low progesterone occur, it is recommended to go to the hospital in time, and take reasonable methods of treatment under the guidance of the doctor to promote the alleviation of the condition.