As an important organ in the human body, the kidney is a more vulnerable organ because it is responsible for filtering some toxic substances that people ingest. Therefore, after getting chronic kidney failure, patients should pay attention to it and treat it actively so that the disease can be cured as soon as possible. So, will there be a big harm if you have chronic kidney failure? The answer is yes, the main hazards of chronic renal failure are as follows: 1. The glomerular filtration rate of the residual kidney units of patients with renal failure increases to compensate for the loss of functional kidney units, which excrete metabolic wastes in the body, but the increased load on the residual kidney units further accelerates glomerular damage, such as causing glomerular hypertrophy. 2, patients with glomerular interstitial inflammatory cell infiltration, which can release growth factors and inflammatory mediators, stimulate the deposition of collagen and increased thylakoid matrix, leading to the appearance of glomerulosclerosis and tubulointerstitial fibrosis. 3, Increased excretion of sodium by the residual renal units in patients with chronic renal failure and reduced sodium intake can lead to a hypovolemic response. 4, Increased urinary protein excretion in patients with chronic renal failure leads to swelling and hypoproteinemia and accelerates tubular glomerular damage. 5, increased secretion of renal tubular ammonia, this can reduce the production of acidosis in patients with chronic renal failure, but accelerates the damage to the renal tubular interstitium. Will there be any big harm if you have chronic renal failure? Through the above introduction, I believe you already know the answer to this question. Chronic renal failure is a relatively serious kidney disease, and patients can only get rid of the disease as soon as possible through active treatment of this method, and restore health as soon as possible. Then, during the treatment, patients also need to pay attention to do a good job with the work.