Waking up easily after two o’clock in the middle of the night involves restless sleep, a type of insomnia that falls under the category of restless sleep. For this condition, if it is a short-term episode, it can be handled with a non-pharmacologic approach. For long-term regular waking up easily in the middle of the night night, you should consider using medications for insomnia, with relatively strong sleeping effects, such as Sulodexamfetamine. If this is still not effective, a more potent medication for insomnia, such as clonidine, may be chosen.