If patients with chronic viral hepatitis B have mutation of hepatitis B virus, the following symptoms and signs will appear: 1. The original symptoms and signs of patients will reappear, or the original symptoms will continue to aggravate, such as nausea, vomiting, fatigue, weakness, and other symptoms of patients will be aggravated, or after improvement, nausea, vomiting, fatigue, and fatigue of patients will reappear again. 2. Part of the patients may be due to Liver function deterioration and necrosis of liver cells cause bilirubin elevation, yellowing of skin and sclera, and yellowing of urine.3. In the test results, liver function of the patients will be improved by active antiviral treatment and hepatoprotective treatment, and then there will be the elevation of ghrelin, ghrelin and bilirubin, which is persistently elevated.4. Some of the patients will have the change of Hepatitis B tri-systems to Hepatitis B tri-systems, suggesting that the patients have the change of minor tri-systems to Hepatitis B tri-systems. It suggests that patients have the possibility of transforming from small triple positive to large triple positive.5, patients’ hepatitis B DNA examination will show that patients’ hepatitis B DNA viral replication will be further strengthened, that is, the viral replication will be more than 500IU/mL and continuously increase. After the occurrence of the above situation, it is considered that the patient is the possibility of mutation of hepatitis B virus, and there is a possibility of resistance to antiviral drugs. At this time, the patient needs to adjust the antiviral drugs in time, and if necessary, to be injected with interferon therapy.