Large ventricular septal defect murmur is a kind of congenital heart disease, which can be treated by doing two methods: blocker sealing or open chest direct vision repair. 1. Occluder sealing: large ventricular septal defect murmur refers to the incomplete development of the ventricular septum during the embryonic period, forming an abnormal traffic and producing left-to-right shunt at the level of the ventricle, and the murmur is also produced as a result. Occluder sealing treatment is suitable for the case of small septal defects with a clear location. The occluder avoids the trauma of open heart surgery incision and various complications caused by general anesthesia and surgery under extracorporeal circulation, and greatly shortens the patient’s hospitalization and postoperative recovery time. 2. Open heart repair under direct visualization: Open heart repair under direct visualization under extracorporeal circulation is suitable for patients with large ventricular septal defects and pulmonary hypertension, which is characterized by large trauma and general anesthesia and extracorporeal circulation, long hospitalization time and permanent scars on the chest after surgery. If the patient has a large ventricular septal defect murmur, it is recommended to consult a doctor in time, under the guidance of the doctor, according to the condition of the ventricular septal defect, to take the appropriate treatment plan.