Patients with reflux esophagitis can be treated with omeprazole, the main effect of which is to inhibit gastric acid secretion, thereby relieving the discomfort caused by reflux esophagitis due to acid reflux. Reflux esophagitis can be triggered by medications, long-term alcohol consumption, smoking, irritating foods, etc. It is caused by reflux of stomach contents, stomach acid, pepsin and bile into the esophagus due to relaxation of the lower esophageal sphincter, weakening of the anti-reflux barrier of the esophageal mucosa, decreased clearing capacity of the esophagus, and delayed gastric emptying. Omeprazole is a proton pump inhibitor, a fat-soluble weakly alkaline drug, easily concentrated in an acidic environment, acting specifically on the tubular vesicles of the apical membrane of the gastric mucosal wall cells, blocking gastric acid secretion, causing a large reduction in the acid content of gastric juice, with a strong inhibitory effect on both basal gastric acid and stimulation-induced gastric acid secretion, and faster pain relief, for reflux esophagitis, and it is recommended to combine with pro-gastrointestinal motility drugs such as morpholine, mosapride, etc. to improve the cure rate. However, it should be noted that omeprazole can be toxic when taken for a longer period of time, with common manifestations such as headache, tinnitus, drowsiness, anxiety and depression. Therefore, drugs should be used under the guidance of a doctor, not blindly on their own.