What is intractable ascites?

Intractable ascites refers to ascites whose symptoms cannot be effectively controlled by diuretics, or which recurs early after the aspiration and release of ascites and cannot be effectively stopped by diuretics. Intractable ascites is a manifestation of the decompensated stage of cirrhosis, and once patients develop intractable ascites, the one-year morbidity and mortality rate can reach 60%. The first line of treatment for intractable ascites is massive pumping and releasing of ascites combined with albumin infusion, which is not an ideal treatment but can effectively relieve the clinical symptoms of patients. The second-line treatment refers to transjugular intrahepatic portosystemic shunt, or TIPS, but TIPS treatment for intractable ascites requires strict screening of patients, and patients who meet the criteria are expected to obtain the maximum benefit from TIPS treatment, while TIPS treatment requires physicians with certain knowledge and skills and high requirements for hardware facilities, so TIPS treatment is still used as the second-line treatment. The ideal treatment for recalcitrant ascites is liver transplantation, but it cannot be widely performed in clinical practice because of the shortage of liver sources and high price. In addition to the above treatment, concentrated transfusion of ascites is also one of the effective methods for the treatment of intractable ascites, and others include the application of vasoactive drugs.