Atrial septal defect is a kind of congenital heart disease, and the treatment nowadays includes interventional occlusion treatment as well as surgical open-heart treatment, and the treatment of interventional occlusion is now belonging to the more popular trend. The material of atrial septal defect occluder is generally made of nickel-titanium alloy, with polymer biofilm attached inside, and polyester polyester or PTFE filling inside the mesh structure. Generally, the interventional blockade is done from the femoral vein through the guidewire to the site of the heart defect, and the release of the blocker is given to block the atrial septal defect, which in turn causes hemodynamic regression and achieves the goal of healing the body. After the procedure, anticoagulant medication should be taken for six months to prevent the blocker from growing blood clots that could affect the body’s health.