Migraines may occur due to emotional stress, work stress, poor rest, and other factors that stimulate neuralgia in the brain. Some patients may not be able to hold on to the medication for migraine, but not any medication can relieve the pain, and migraine disease needs to be treated with medication under the guidance of experts. Migraine is the most common type of primary headache, mainly manifested by episodes of moderate to severe, throbbing headache, which is mostly hemiplegic and usually lasts for 4 to 72 hours. Epidemiological studies show that about 6-7% of men and 20% of women suffer from this disease. The higher incidence in women than men is due to the X-chromosome chain inheritance of migraine. Moreover, because migraine is characterized by high morbidity, high disability, high underdiagnosis and low control rate: the World Health Organization (WHO) has ranked severe migraine as one of the most serious chronic dysfunctional diseases along with physical paralysis, mental disorders and dementia. Frequent migraine attacks will affect patients’ life and work, and most directly affect sleep, because lack of sleep will make them lose energy during the day, and their work will be greatly affected. Moreover, some patients often have migraine attacks when they are working, which is very delayed. At the same time, when people suffer from headache disease for a long time, their personality changes and they often become irritable. In addition, because the headache is not cured for a long time, life is greatly affected, psychological fragility, loss of confidence, and over time, it will have a negative impact on people’s cardiovascular and cerebrovascular, and clinically, cerebral thrombosis, hypertension and cerebral hemorrhage are also more common after headache attack. The following are the clinical manifestations of the main types of migraine: Migraine without aura Migraine without aura is the most common type of migraine, accounting for about 80%. There may be no obvious aura symptoms before the onset of migraine, but some patients have mental disorder, fatigue, yawning, loss of appetite and general discomfort before the onset of migraine, and the pain may be triggered by menstrual flow, alcohol consumption and hunger on an empty stomach. The headache is slowly aggravated, with recurrent episodes of frontotemporal pain on one or both sides, which is pulsatile. It is often accompanied by nausea, vomiting, photophobia, phonophobia, sweating, general discomfort, and scalp tenderness. Compared with migraine with aura, migraine without aura has a higher frequency of attacks, which can seriously affect patients’ work and life, and often requires frequent application of painkillers. A new type of headache, “medication-overuse headache,” is likely to occur in combination. Migraine with aura Migraine with aura accounts for about 10% of migraineurs. Precursors such as lethargy, lack of concentration, and yawning may be present for hours to days before the onset of the attack. The most common aura is visual aura, such as blurred vision, dark spots, flashes of light, bright spots and bright lines, or distortion of vision; followed by sensory aura, with sensory symptoms mostly distributed in the face-hand region; verbal and motor aura are rare. Aura symptoms usually develop gradually within 5-20 minutes and last no more than 60 minutes; different aura can appear one after another. Headache occurs at the same time as or within 60 minutes after the aura and is manifested as a one-sided or bilateral frontotemporal or retro-orbital pulsating headache, often accompanied by nausea, vomiting, photophobia or phonophobia, pallor or sweating, polyuria, irritability, odor terror and fatigue, etc. Head and facial edema and temporal artery prominence are seen. The headache can be aggravated by activity and relieved by sleep. The pain usually peaks in 1~2 hours and lasts for 4~6 hours or more than 10 hours, and can last for several days in severe cases. After the headache subsides, there are often fatigue, lethargy, irritability, weakness and poor appetite.