Positive anti-cyclic citrullinated peptide (CCP) antibody in the Rheumatology Pentameter means positive anti-cyclic citrullinated peptide (CCP) antibody, which generally represents the possibility of rheumatoid arthritis, but it should be analyzed in conjunction with the patient’s clinical symptoms and other test results. Anti-cyclic citrullinated peptide antibody, one of the signature antibodies of rheumatoid arthritis, has high sensitivity and specificity for rheumatoid arthritis, and is a highly specific indicator for early diagnosis of rheumatoid arthritis. Positive anti-cyclic citrullinated peptide antibody is mostly seen in rheumatoid arthritis, and also has a certain reference value for the prognosis of rheumatoid arthritis. A positive anti-cyclic citrullinated peptide antibody alone cannot confirm the diagnosis of rheumatoid arthritis. It should be combined with the patient’s clinical symptoms, such as morning stiffness, symmetric small joint pain, swelling, joint deformity, etc., as well as other tests, such as imaging tests, etc., to make a comprehensive analysis before the diagnosis of rheumatoid arthritis can be confirmed. If anti-cyclic citrullinated peptide antibody is found to be positive, it is recommended to go to the hospital in time and cooperate with the physician to improve further treatment in order to clarify the diagnosis.