Most of the cancer patients will enter the terminal stage of advanced cancer due to the development of the disease and the recurrence of the lesions. At this time, the patients’ symptoms are diverse and complex, and there are no specific symptoms. Clinically, it is believed that patients with advanced cancer will experience pain, gastrointestinal symptoms, cachexia, nutritional disorders, and a series of symptoms concerning the respiratory system and central nervous system before dying: 1. Pain: It is one of the typical manifestations of patients with advanced cancer before dying, not only the pain caused by the lesions involving many organs of the body such as nerves and blood vessels, but also the complex headache and fever caused by treatment and psychology, etc. Pain reactions; 2. Gastrointestinal symptoms: when the lesions involve the gastrointestinal tract, gastrointestinal dysfunction may be induced, leading to discomfort such as nausea, vomiting, abdominal distension and abdominal pain; 3. Cachexia: mainly caused by excessive consumption of nutrients by the body and infiltration of organ tissues by cancer cells, patients have a series of clinical manifestations such as weakness of limbs, mental depression and sleep disorders; 4. Nutritional disorders: cancer Before dying, patients with advanced cancer often have decreased appetite, which may cause physical weakness, weight loss, anemia, malnutrition, metabolic abnormalities and other uncomfortable symptoms; 5.Respiratory system symptoms: difficulty in breathing is one of the spontaneous manifestations of terminal cancer patients, which may also be accompanied by coughing, coughing up blood, difficulty in swallowing, chest tightness, chest pain, shortness of breath, rapid heartbeat and other symptoms, which may seriously affect patients’ quality of life; 6.Neurological system 6. Neurological symptoms: depression, anxiety, irritability, sadness and other emotions are common, which are mainly caused by the development of disease and treatment pain.