Pepsinogen Ⅰ 35ng/ml is the decrease of pepsinogen Ⅰ, only rely on the result of pepsinogen Ⅰ can not accurately determine its severity, it is recommended to further improve the related examination such as pepsinogen Ⅱ, gastroscopy and so on. Serum pepsinogen Ⅰ reflects the number of glands and cells of gastric mucosa, and also indirectly reflects the secretion function of different parts of gastric mucosa, the normal value range is 60~240ng/ml. Pepsinogen Ⅰ 35ng/ml for pepsinogen Ⅰ reduced, usually suggests that the patient’s gastric mucosa cell secretion activity is reduced, may be related to improper diet and rest, alcohol, drug factors, etc., and may be atrophic gastritis or gastric mucosal atrophy and other diseases caused. However, pepsin Ⅰ test alone can not accurately determine, but also need to refer to the pepsinogen Ⅰ, Ⅱ ratio. It is recommended to go to the hospital for pepsinogen examination. If the ratio is too low, it often suggests atrophic gastritis, and further gastroscopy is needed to clarify the condition of gastric mucosa and gastric fundus, and then the doctor will judge the degree of gastric mucosa atrophy according to the examination results. If pepsinogen Ⅰ 35 ng / ml, should consult the doctor in time, by the doctor to make a judgment, clear the cause of the disease, under the guidance of the doctor for treatment. You can’t diagnose the disease on your own by relying only on a single pathological change, so as not to delay the treatment.