Prolonged application of povidone-iodine may cause dryness and peeling of the wound and surrounding skin, and it is recommended to stop using it for an appropriate period of time after the occurrence of such symptoms. Povidone-iodine is a strong oxidizing agent, and its main function is to sterilize and disinfect, which is often used to disinfect the local skin of patients before clinical operation. If it is used frequently, it may cause the barrier function of the skin to deteriorate, damage the stratum corneum of the skin, and lead to dryness; and it may also damage the normal flora of the skin, resulting in secondary infections. In addition, long-term application of povidone-iodine can cause the body to develop drug resistance; the use of povidone-iodine can also cause skin pigmentation, and long-term application of povidone-iodine can lead to prolongation of the time needed for pigment metabolism. Therefore, when applying povidone-iodine, the medication should be used in accordance with the doctor’s prescription in order to avoid adverse consequences.